Nothing, that's the way NTSF:SD:SUV:: creator Paul Scheer looks in real life. He's simply wearing a wig on the show
Now this is a surprise... With "hair" he looks much younger, and without "hair" older, but solid.
(I love the way your comment matches Summer's expression in your avatar, btw).
Now if you want to see something weird that happened to another member of the NTSF:SD:SUV:: cast, take a look at this video featuring Karen Gillan at the "Guardians of the Galaxy" panel at San Diego Comic-Con.
They are funny guys, as I see.